Methyl iodide → HCID 13531611, compound

HRID 370475Notes

Reaction equation

HRID 370475 reaction equation
[N+:1]([C:4]1[O:5][C:6]2[CH:18]=[CH:17][C:16]([CH2:19][N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[CH:15][C:7]=2[C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([O-:3])=[O:2].[CH3:26][I:27]>CC(C)=O>[I-:27].[CH3:26][N+:20]1([CH2:19][C:16]2[CH:17]=[CH:18][C:6]3[O:5][C:4]([N+:1]([O-:3])=[O:2])=[C:8]([C:9]4[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=4)[C:7]=3[CH:15]=2)[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1

Participants

4

Reactant 2

HCID 6328Methyl iodide2×HCID 13912220HCID 13912220, compound2×

Product 1

HCID 13531611HCID 13531611, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a 1.9 g. (0.0056 mole) sample of N-(2-nitro-3-phenyl-5-benzofuranylmethyl)morpholine (the product of Example 6) in 100 ml. of acetone is added 1.0 g. of methyliodide. After setting for one week, an additional 1.0 g. of methyliodide is added. After 1 day of stirring, the precipitated solid is separated by filtration and extracted with 300 ml. of refluxing ethanol to provide yellow crystals of N-methyl-N-(2-nitro-3-phenyl-5-benzofuranylmethyl)morpholinium iodide, m.p. 226°-230° C., having the structure ##STR15##

Workup

  1. waitAfter setting for one week
  2. customthe precipitated solid is separated by filtration
  3. extractionextracted with 300 ml

Sources & evidence

ORD record
ord-10f5a5607c8f483a864fb7d6e99a3b1e
Source dataset
uspto-grants-1985_07
Patent number
US04526896

Reaction notes

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