Chloroform → HCID 178419493, compound

HRID 370489Notes

Reaction equation

HRID 370489 reaction equation
[NH:1]1[C:5]([CH2:6][C:7]2[CH:8]=[CH:9][C:10]3[O:14][CH:13]=[C:12]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[C:11]=3[CH:21]=2)=[N:4][N:3]=[N:2]1.C(Cl)(Cl)Cl.[Br:26]Br>O1CCOCC1>[Br:26][C:13]1[O:14][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][C:5]3[NH:1][N:2]=[N:3][N:4]=3)=[CH:21][C:11]=2[C:12]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

5

Reactant 3

HCID 6212ChloroformHCID 24408BromineHCID 178420131HCID 178420131, compound

Product 1

HCID 178419493HCID 178419493, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
0 °C

Procedure

To a stirred solution of 2.8 g. (0.01 mole) of 5-tetrazolylmethyl-3-phenylbenzofuran in 100 ml. of chloroform and 20 ml. of dioxane is added dropwise 1.6 g. (0.01 mole) of bromine. After 45 minutes the mixture is cooled to 0° C., then the product is separated by filtration and washed with chloroform. Recrystallization from aqueous ethanol provides 2-bromo-3-phenyl-5-(1H-tetrazol-5yl)methylbenzofuran m.p. 215°-217° C.

Workup

  1. customthe product is separated by filtration
  2. washwashed with chloroform
  3. customRecrystallization from aqueous ethanol

Sources & evidence

ORD record
ord-e66d2477619145b596ed796ea5c59422
Source dataset
uspto-grants-1985_07
Patent number
US04526896

Reaction notes

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