Sodium Hydroxide → HCID 178507500, compound

HRID 370534Notes

Reaction equation

HRID 370534 reaction equation
[N+:1]([C:4]1[CH:17]=[CH:16][CH:15]=[CH:14][C:5]=1[C:6]([NH:8][C:9]1[NH:13][N:12]=[N:11][N:10]=1)=[O:7])([O-])=O.[OH-].[Na+].[H][H]>[Pd].C(O)C>[NH2:1][C:4]1[CH:17]=[CH:16][CH:15]=[CH:14][C:5]=1[C:6]([NH:8][C:9]1[NH:13][N:12]=[N:11][N:10]=1)=[O:7]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 178418361HCID 178418361, compoundHCID 178522658HCID 178522658, compound

Product 1

HCID 178507500HCID 178507500, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution was prepared from 19 g of 2-nitro-N-(1H-tetrazol-5-yl)benzamide in 100 ml of aqueous 1 N sodium hydroxide and 100 ml of ethanol. A 0.5-gram quantity of 5% Pd/C catalyst was added and the mixture was hydrogenated in a Parr apparatus at 1520 mm Hg pressure until uptake of hydrogen stopped. The catalyst was removed by filtration and the filtrate was treated with aqueous 1 N hydrochloric acid. The white solid which formed was separated by filtration and dried to give 2-amino-N-(1H-tetrazol-5-yl)benzamide melting at about 253°-254° C.

Workup

  1. customThe catalyst was removed by filtration
  2. additionthe filtrate was treated with aqueous 1 N hydrochloric acid
  3. customThe white solid which formed
  4. customwas separated by filtration
  5. customdried

Sources & evidence

ORD record
ord-ad54e2e01e704c408f6b7d2c2bc810da
Source dataset
uspto-grants-1985_07
Patent number
US04526979

Reaction notes

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