反应详情

A mixture of 46.4 g of 1,3-dihydro-4-(4-methoxybenzoyl)-5-methyl-2H-imidazol-2-one and 200 ml of acetic anhydride is refluxed for 2 hours. The mixture is distilled to remove 100 ml of acetic anhydride and acetic acid; this is replaced by fresh acetic anhydride and refluxing is resumed. After a total of 4 hours of reflux, excess acetic anhydride is evaporated under reduced pressure and the resulting residue is crystallized from ethanol to give 1,3-diacetyl-1,3-dihydro-4-(4-methoxybenzoyl)-5-methyl-2H-imidazol-2-one melting at about 123°-125° C.

1. temperatureis refluxed for 2 hours
2. distillationThe mixture is distilled
3. customto remove 100 ml of acetic anhydride and acetic acid
4. temperaturerefluxing
5. temperatureAfter a total of 4 hours of reflux
6. customexcess acetic anhydride is evaporated under reduced pressure
7. customthe resulting residue is crystallized from ethanol