反应详情

温度

25 °C

5-(Bromomethyl)-1,3-dihydro-4-(4-methoxybenzoyl)-2H-imidazol-2-one (3.1 g) is dissolved in 80 ml of acetic acid by warming on a steam bath. The solution obtained is allowed to cool to about 25°-45° C. and 1.7 g of silver acetate is added. The mixture is stirred at 25° C. for 16 hours and the precipitate which forms (silver bromide) is removed by filtration. The filtrate is concentrated to about 10 ml and a solid crystallizes. This is separated by filtration and recrystallized from acetic acid to give 4-[(acetyloxy)methyl]-1,3-dihydro-5-(4-methoxybenzoyl)-2H-imidazol-2-one melting at about 155°-162° C. This compound has the following structural formula: ##STR7##

1. temperatureby warming on a steam bath
2. customThe solution obtained
3. temperatureto cool to about 25°-45° C.
4. customis removed by filtration
5. concentrationThe filtrate is concentrated to about 10 ml
6. customa solid crystallizes
7. customThis is separated by filtration
8. customrecrystallized from acetic acid