Ammonium formate → 5,9-Bis-(hydroxymethyl)-1-oxa-4,7,10-triazacyclododecane

Participants

Reaction Conditions

Reaction Steps

5,9-Bis(benzyloxymethyl) -1-oxa-4,7,10-triazacyclododecane (0.24 g, 0.6 mmol) was dissolved in methanol (10 ml) . Ammonium formate (0.20 g, 3 mmol) and 10% Palladium on carbon (0.40 g) were added and the mixture was stirred under a nitrogen atmosphere at 50° C. for 16 hours. The catalyst was filtered off and washed with methanol (5 ml). The filtrate was evaporated and the 5,9-Bis-(hydroxymethyl)-1-oxa-4,7,10-triazacyclododecane was isolated as a colourless oil. Yield 0.12 g (86%).

Provenance & Evidence