Water → HCID 13477118, compound

Participants

Reaction Steps

To a solution of 3.5 g (0.014 m), of 2-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl)ethylamine of Example 6 and 1.4 g (0.014 m) of triethylamine in 50 ml of CH2Cl2, 1.6 g (0.014 m) of methanesulfonyl chloride was added dropwise maintaining the temperature between 15°-20° C. The mixture was stirred 45 minutes, then poured into water. The CH2Cl2 layer was separated, washed with water, dried (Na2SO4), filtered and evaporated to give a foamy solid. Recrystallization from approximately 40 ml of toluene gave 2.27 g (49%) of N-(2-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl)ethyl)methanesulfonamide, m.p. 104°-106° C.

Provenance & Evidence