Trifluoroacetic acid → HCID 6915775, compound

HRID 3706Notes

Reaction equation

HRID 3706 reaction equation
C([O:5][C:6](=[O:56])[CH:7]([NH:18][C:19](=[O:55])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[S:26][S:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[C:34](=[O:54])[NH:35][CH:36]([C:47]([O:49]C(C)(C)C)=[O:48])[CH2:37][CH2:38][CH2:39][C:40]([O:42]C(C)(C)C)=[O:41])[CH2:8][CH2:9][CH2:10][C:11]([O:13]C(C)(C)C)=[O:12])(C)(C)C.FC(F)(F)C(O)=O.C1(OC)C=CC=CC=1>ClCCl>[C:6]([CH:7]([NH:18][C:19]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[S:26][S:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[C:34]([NH:35][CH:36]([CH2:37][CH2:38][CH2:39][C:40]([OH:42])=[O:41])[C:47]([OH:49])=[O:48])=[O:54])=[O:55])[CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])([OH:56])=[O:5]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 76080001HCID 76080001, compound

Product 1

HCID 6915775HCID 6915775, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This compound was prepared according to the procedure described in Example 50 using [S-(R*,R*)]-2-{2-[2-(1,4-bis-tert-butoxycarbonyl-butylcarbamoyl)phenyldisulfanyl]-benzoylamino}-hexanedioic acid di-tert-butyl ester (1.1 g, 1.4 mmol) from Example 10 mL dichloromethane, 10 mL trifluoroacetic acid, and 1 mL anisole. The crude product was recrystallized from methanol/dimethylformamide/water to afford 0.6 of the title compound, mp 259°-260° C.

Workup

  1. customThis compound was prepared
  2. customThe crude product was recrystallized from methanol/dimethylformamide/water

Sources & evidence

ORD record
ord-c0c63113194641109ceb64f308eed198
Source dataset
uspto-grants-1998_03
Patent number
US05734081

Reaction notes

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