HCID 13175960, compound → HCID 13175966, compound

HRID 370600Notes

Reaction equation

HRID 370600 reaction equation
[NH:1]([C:8]1[S:9][C:10]([C:13]2[CH2:20][S:19][CH:18]3[N:15]([C:16](=[O:30])[CH:17]3[NH:21][C:22](=[O:29])[CH2:23][C:24]3[S:25][CH:26]=[CH:27][CH:28]=3)[C:14]=2[C:31]([O:33]C(C2C=CC=CC=2)C2C=CC=CC=2)=[O:32])=[CH:11][N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)=O>[NH:1]([C:8]1[S:9][C:10]([C:13]2[CH2:20][S:19][CH:18]3[N:15]([C:16](=[O:30])[CH:17]3[NH:21][C:22](=[O:29])[CH2:23][C:24]3[S:25][CH:26]=[CH:27][CH:28]=3)[C:14]=2[C:31]([OH:33])=[O:32])=[CH:11][N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 13175960HCID 13175960, compound

Product 1

HCID 13175966HCID 13175966, compoundYield 59.3%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

3-(2-Anilinothiazol-5-yl)-2-benzhydryloxycarbonyl-8-oxo-7-(thien-2-yl-acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene (0.9 g) is treated with formic acid (9 cc) by following the procedure described in Reference Example 1, and 3-(2-anilinothiazol-5-yl)-2-carboxy-8-oxo-7-(thien-2-yl-acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene (0.4 g) is obtained in the form of a yellow solid.

Sources & evidence

ORD record
ord-e045095416604cffaeaf441aa79c912e
Source dataset
uspto-grants-1985_07
Patent number
US04526962

Reaction notes

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