Hydrochloric Acid → HCID 86740187, compound

Participants

Reaction Steps

690 ml of 26B was stirred in 25 ml of trifluoroacetic acid at room temperature for 10 minutes. Then 5 ml of concentrated hydrochloric acid was added drop-by-drop. The resulting solution was stirred at room temperature for three hours, then 16 ml of water was added, and the resulting solution was stirred at room temperature for 16 hours. Then the solvent was evaporated, the residue was dissolved in 30 ml of 2N hydrochloric acid and the resulting solution was extracted with ether, and the solvent was evaporated at a temperature below 40° C. to give methyl (S)-(E)-4-amino-5-fluoro-2-pentenoate hydrochloride (26C), as a pale yellow paste.

Provenance & Evidence