LY 97241 → 4-{4-[Ethyl(heptyl)amino]butyl}aniline

HRID 370639Notes

Reaction equation

HRID 370639 reaction equation
[CH2:1]([N:3]([CH2:11][CH2:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH3:2]>[Pd].C(O)C>[CH2:1]([N:3]([CH2:11][CH2:12][CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]([NH2:21])=[CH:19][CH:20]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH3:2]

Participants

4

Reactant 1

HCID 175064LY 97241

Product 1

HCID 135610994-{4-[Ethyl(heptyl)amino]butyl}aniline

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 2.03 g. (6.3mM) of N-ethyl-N-n-heptyl-4(4-nitrophenyl)butylamine in 100 ml of 2B ethanol containing 1 g of 5% palladium on carbon was stirred under hydrogen at 50 p.s.i. for sixteen hours at 25° C. The reaction mixture was filtered and the solvent was removed by evaporation under reduced pressure to give 1.49 g of N-ethyl-N-n-heptyl-4-(4-aminophenyl)butylamine as an oil.

Workup

  1. waitfor sixteen hours at 25° C
  2. filtrationThe reaction mixture was filtered
  3. customthe solvent was removed by evaporation under reduced pressure

Sources & evidence

ORD record
ord-0fa95705b651490c99f8c1858cec6654
Source dataset
uspto-grants-1985_07
Patent number
US04528177

Reaction notes

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