Ethanol → HCID 10095884, compound

Participants

Reaction Steps

13.8 g (30 mmol) of 2-(4-diphenylmethylpiperazinyl)-1-(2,3,4-trimethoxyphenyl)ethanone was dissolved in a mixed solvent consisting of 100 ml of ethanol and 30 ml of chloroform, followed by addition of 2.27 g (60 mmol) of sodium borohydride under ice-cooled conditions over 20 minutes. The resultant mixture was stirred at room temperature for 2 hours, followed by addition of 50 ml of an aqueous saturated solution of ammonium chloride and by further addition of 100 ml of water. The resultant mixture was extracted with 200 ml of ethyl acetate, and the organic layer was successively washed with water and saturated saline and then dried over anhydrous sodium sulfate. The solvent was removed, and the residue was recrystallized from a mixed solvent of chloroform and ethanol to give 9.70 g of 2-(4-diphenylmethylpiperazinyl)-1-(2,3,4-trimethoxyphenyl)ethanol as white crystals (yield: 70%).

Provenance & Evidence