Potassium sodium tartarate → HCID 178442150, compound

Participants

Reaction Steps

A solution of 2.0 g of trans-4-(p-pentylphenyl)cyclohexanecarbonitrile in 60 ml of methylene chloride was placed at -78° C. under argon gasification in a sulphonation flask equipped with a mechanical stirrer and treated within 3 minutes with 13.2 ml of a 1.5M solution of diisobutylaluminium hydride in toluene. The mixture was subsequently stirred for a further 2 hours with gradual warming to room temperature, then poured cautiously into 100 ml of 10% potassium sodium tartrate solution and extracted three times with 200 ml of diethyl ether each time. The organic phases were washed twice with 100 ml of water each time, dried over potassium carbonate and concentrated. There were obtained 1.98 g of trans-4-(p-pentylphenyl)cyclohexanecarboxaldehyde (purity 86.1%) as a viscous oil which was used without additional purification.

Provenance & Evidence