Cyanogen Bromide → HCID 13324092, compound

Participants

Reaction Steps

To a stirred mixture of CNBr (5.9 g, 0.056 mole), K2CO3 (8.6 g) and CHCl3 (80 ml) was added dropwise 3-(1-methyl-4-piperidinyl)-1,2-benzisothiazole (11.0 g, 0.051 mole) in CHCl3 (30 ml). The mixture was stirred and refluxed for 4 hours and thereafter cooled and filtered. The filtrate was concentrated in vacuo to a solid. The solid was triturated with hexane and collected to yield 13.5 g of the desired compound. Recrystallization from MeOH--H2O (twice) yielded 4.5 g (36%) of the benzisothiazole, m.p. 118°-120°.

Provenance & Evidence