Methanol → HCID 13519406, compound

Participants

Reaction Steps

A mixture of 3-(1-cyano-4-piperidinyl)-1,2-benzisothiazole (11.7 g, 0.048 mole), KCN (3.1 g) and MeOH (145 ml) was stirred and refluxed for 4 hours, and then stirred at ambient temperature for 14 hours. The MeOH was removed in vacuo and the residue diluted with water. The aqueous suspension was extracted with chloroform and the chloroform extract was washed with water and dried over MgSO4. Thereafter, the chloroform was evaporated in vacuo to yield 12.4 g of a solid. Recrystallization from EtOAc yielded 6.0 g (45.2%) of a solid. An analytical sample was obtained by a second recrystallization of a 3.5 g sample. The resultant solid (2.6 g) had a melting point of 144°-146° C.

Provenance & Evidence