HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 13477661, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Ethyl-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid--hydrogen chloride (1/1) | HCID 3062436 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | HCID 13477661 | HCID 13477661 | 96.6% |
Reaction Steps
A mixture of 2.69 g of 1-ethyl-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride, 5.4 ml 90% formic acid, 3.5 ml of 37% formalin and 0.70 g of potassium carbonate was heated for 5 hours under reflux. The reaction mixture was neutralized with 20% aqueous sodium hydroxide. The precipitate was filtered and recrystallized from a mixture of chloroform and methanol to give 1.70 g of the title compound as colorless needles, M.p. 244°-246° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04528287 |
| Source dataset | uspto-grants-1985_07 |
| ORD ID | ord-33cc7a4efff64b8caf4bf335f803e1b5 |
| Source note | uspto-grants-1985_07 |