Sodium Carbonate → HCID 20275256, compound

HRID 370718Notes

Reaction equation

HRID 370718 reaction equation
[BH4-].[Na+].[F:3][C:4]1[C:10]([F:11])=[C:9]([F:12])[CH:8]=[CH:7][C:5]=1[NH2:6].[C:13]([O-])(=O)[CH3:14].[Na+].[C:18](=O)([O-])[O-].[Na+].[Na+]>O.C(O)(=O)C.CC(C)=O>[F:3][C:4]1[C:10]([F:11])=[C:9]([F:12])[CH:8]=[CH:7][C:5]=1[NH:6][CH:13]([CH3:14])[CH3:18]

Participants

8

Reactant 4

HCID 10340Sodium CarbonateHCID 774682,3,4-TrifluoroanilineHCID 517045Sodium AcetateHCID 4311764Sodium borohydride

Product 1

HCID 20275256HCID 20275256, compound

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

7.70 g of sodium borohydride was added to a mixture of 3.70 g of 2,3,4-trifluoroaniline, 10.30 g of sodium acetate, 20 ml of acetone, 19.6 ml of acetic acid and 39 ml of water under stirring and ice-cooling. After 2 hours, the reaction mixture was made alkaline with sodium carbonate and extracted with benzene. The extract was washed with NaCl saturated water, dried and the solvent was evaporated to give 3.17 g of 2,3,4-trifluoro-N-isopropyl aniline as colorless oil.

Workup

  1. temperatureice-cooling
  2. extractionextracted with benzene
  3. washThe extract was washed with NaCl saturated water
  4. customdried
  5. customthe solvent was evaporated

Sources & evidence

ORD record
ord-e742109cb43844c4a5da1e2a94db3853
Source dataset
uspto-grants-1985_07
Patent number
US04528287

Reaction notes

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