Methyl iodide → HCID 20275273, compound

Participants

Reaction Steps

A mixture of 1.2 g (5 mmole) of 7-chloro-2-hydroxy-5-methylthiotriazolo[1,5-c]pyrimidine (from Example 7), 2 g (14 mmole) of methyl iodide, 1.2 g (5 mmole) of sodium methoxide (as a 25% methanolic solution), and 50 ml of methanol was heated at its reflux temperature for two hours and then cooled. The solid was collected by filtration and recrystallized from a 50:50 mixture of glyme and hexane to provide yellow crystals of 7-chloro-2-methoxy-5-methylthiotriazolo[1,5-c]pyrimidine, m.p. 243°-244° C. Analysis: Calculated for C7H7ClN4OS: %C, 36.4; %H, 3.1; %N, 24.3; Found: %C, 36.3; %H, 2.9; %N, 24.2.

Provenance & Evidence