Potassium Carbonate → HCID 20275393, compound

Participants

Reaction Steps

Following the procedure of Example 3, but substituting an equivalent amount of methyl 5-(2-acetylthiomethyl-propionamido)-nicotinate, obtained as disclosed in Example 12, for methyl 2-(2-acetylthiomethyl-propionamido)-nicotinate and substituting an equivalent amount of potassium carbonate for sodium hydroxide and maintaining the reaction mixture under stirring for six hours at room temperature, 5-(2-mercaptomethyl-propionamido)-nicotinic acid is obtained after purification on a silica gel column (eluent methylene chloride/methanol 99:1); m.p. 160°-165° C., from acetone.

Provenance & Evidence