HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 5-(METHYLAMINO)NICOTINIC ACID
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 5-Bromonicotinic acid | HCID 88707 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | 5-(METHYLAMINO)NICOTINIC ACID | HCID 2050103 | — |
Reaction Steps
The intermediate methyl 5-methylamino-nicotinate has been obtained as follows: reaction of methylamine (40% in water) with 5-bromo-nicotinic acid in autoclave at 140° C. for seven hours gives 5-methylamino-nicotinic acid, m.p. 239°-242° C. from ethanol/water; this acid reacts with SOCl in methanol under reflux for seven hours to afford the ester (methyl 5-methylaminonicotinate; m.p. 113°-115° C., from petroleum ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04528296 |
| Source dataset | uspto-grants-1985_07 |
| ORD ID | ord-acda068c83224b3d9a07b870b2b38800 |
| Source note | uspto-grants-1985_07 |