HCID 20275380, compound → HCID 20275367, compound

HRID 370735Notes

Reaction equation

HRID 370735 reaction equation
C([S:4][CH2:5][CH:6]([CH3:21])[C:7]([N:9]([C:11]1[CH:12]=[N:13][CH:14]=[C:15]([CH:20]=1)[C:16]([O:18]C)=[O:17])[CH3:10])=[O:8])(=O)C.C(SCC(C)C(NC1N=CC=CC=1C(OC)=O)=O)(=O)C>>[SH:4][CH2:5][CH:6]([CH3:21])[C:7]([N:9]([C:11]1[CH:12]=[N:13][CH:14]=[C:15]([CH:20]=1)[C:16]([OH:18])=[O:17])[CH3:10])=[O:8]

Participants

3

Reactant 2

HCID 20275380HCID 20275380, compoundHCID 20275394HCID 20275394, compound

Product 1

HCID 20275367HCID 20275367, compound

Procedure

Following the procedure of Example 3, but substituting an equivalent amount of methyl 5-(2-acetylthiomethyl-N-methyl-propionamido)-nicotinate, obtained as disclosed in Example 16, for methyl 2-(2-acetylthiomethyl-propionamido)-nicotinate, 5-(2-mercaptomethyl-N-methyl-propionamido)-nicotinic acid is obtained; m.p. 190°-192° C., from methanol.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-801129c69d044861b9c78bc9705866be
Source dataset
uspto-grants-1985_07
Patent number
US04528296

Reaction notes

Loading…