Methyl 2-aminopyridine-4-carboxylate → HCID 20275365, compound

Participants

Reaction Steps

Following the procedure of Example 1, but substituting an equivalent amount of methyl 2-amino-isonicotinate and 2-acetylthiomethyl-3-phenyl-propionic acid respectively for methyl 2-amino-nicotinate and 2-acetylthiomethyl-3-phenyl-propionic acid, using pyridine as reaction solvent, maintaining the reaction mixture at 50°-60° C. for five hours and purifying by chromatography on silica gel column (eluent, petroleum ether/ether 7:3), methyl 2-(2-acetylthiomethyl-3-phenyl-propionamido)-isonicotinate is obtained as an oil which is transformed into the corresponding hydrochloride with an alcoholic solution of hydrogen chloride; m.p. 137°-139° C., from acetone/ether.

Provenance & Evidence