Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,2,4-Thiadiazole, 5-chloro-3-(trichloromethyl)- | HCID 79930 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | N-(Cyclohex-1-en-1-yl)-2-hydroxy-N-methylacetamide | HCID 54484327 | — |
| Solvent | Methyl Isobutyl Ketone | HCID 7909 | — |
| Product | HCID 13304366 | HCID 13304366 | 84.8% |
Reaction Steps
3.1 g (0.07 mol) of lithium hydroxide hydrate are added in portions, at 0° C., to 16.7 g (0.07 mol) of 3-trichloromethyl-5-chloro-1,2,4-thiadiazole and 11.8 g (0.07 mol) of hydroxyacetic acid N-methyl-N-cyclohex-1-enylamide in 100 ml of methyl isobutyl ketone, and the mixture is stirred for 30 minutes at 0° C. and then overnight at 25° C. After water has been added, the reaction product which separates out as a solid is filtered off under suction, washed and dried. 22.0 g (84.8% of theory) of 3-trichloromethyl-1,2,4-thiadiazol-5-yl-oxyacetic acid N-methyl-N-cyclohexen-1-yl-amide are obtained in the form of beige-colored crystals of melting point 78° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04528379 |
|---|
| Source dataset | uspto-grants-1985_07 |
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| ORD ID | ord-5df05e4225974b2e83f5b6dc497ec804 |
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| Source note | uspto-grants-1985_07 |
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