m-Chloroperbenzoic acid → 4,5-Bis(4-methoxyphenyl)-2-(2-pyridylsulfinyl)imidazole

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Reaction Steps

A solution of 2.164 g of 3-chloroperbenzoic acid (80%) in 150 ml of dichloromethane is added dropwise to a solution of 3.90 g of 4,5-bis(4-methoxyphenyl)-2-(2-pyridylthio)imidazole in 100 ml of dichloromethane. The solution is stirred for 3 hours at room temperature, washed with sodium bicarbonate solution, dried over sodium sulfate, and concentrated under vacuum to dryness. The residue is chromatographed on 150 g of silica gel with acetone/hexane, thus producing 3.42 g of 4,5-bis(4-methoxyphenyl)-2-(2-pyridylsulfinyl)imidazole as an amorphous foam.

Provenance & Evidence