3-Amino-4-methoxy-1,2,5-thiadiazole 1-oxide → HCID 23312508, compound

HRID 370816Notes

Reaction equation

HRID 370816 reaction equation
CN(CC1N=C(OCCCN)C=CC=1)C.NC1C(OC)=NS(=O)N=1.[NH2:25][C:26]1[C:30]([NH:31][CH2:32][CH2:33][CH2:34][O:35][C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([CH2:42][N:43]3[CH2:48]CCC[CH2:44]3)[N:37]=2)=[N:29][S:28](=O)[N:27]=1>>[NH2:25][C:26]1[C:30]([NH:31][CH2:32][CH2:33][CH2:34][O:35][C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([CH2:42][N:43]([CH3:44])[CH3:48])[N:37]=2)=[N:29][S:28][N:27]=1

Participants

4

Reactant 3

HCID 159612163-Amino-4-methoxy-1,2,5-thiadiazole 1-oxideHCID 15961340HCID 15961340, compoundHCID 21292013HCID 21292013, compound

Product 1

HCID 23312508HCID 23312508, compound

Procedure

When a methanolic solution of 3-(6-dimethylaminomethyl-2-pyridyloxy)propylamine [prepared according to published U.K. patent application No. 2,098,988] is reacted with 3-amino-4-methoxy-1,2,5-thiadiazole 1-oxide according to the general procedure described in U.K. patent application No. 2,067,987 and the resulting 3-amino-4-[3-(6-piperidinomethyl-2-pyridyloxy)propylamino]-1,2,5-thiadiazole 1-oxide is successively reacted by the general procedure described in Example 1, Step A, and then by either Example 1, Step B, or Example 10, the title compound is thereby produced.

Sources & evidence

ORD record
ord-d705876682584aef9962aebb0b9277cf
Source dataset
uspto-grants-1985_07
Patent number
US04528375

Reaction notes

Loading…