2',4'-Dihydroxyacetophenone → HCID 13477606, compound

Participants

Reaction Steps

A mixture of potassium carbonate (anhydrous, 31.7 g) and cesium carbonate (catalytic amount) is pulverized with mortar and pestle, then added to a solution of 2,4-dihydroxyacetophenone (35 g) in acetone (250 ml). The mixture is refluxed for 30 minutes. A solution of m-nitrobenzyl bromide (50 g) in acetone (100 ml) is added in one portion and the reaction refluxed for 3 days. After cooling to room temperature, water is added until a precipitate forms. The product is collected on a Buchner funnel, washed with water and ether. Recrystallization from acetone provides 36.9 g (56% yield) of needles, m.p. 117°-118° C.

Provenance & Evidence