HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → N-Cyclohexyl 4-Chlorobenzimidoyl Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Chloro-N-cyclohexylbenzamide | HCID 225461 | — |
| Product | N-Cyclohexyl 4-Chlorobenzimidoyl Chloride | HCID 13477600 | — |
Reaction Steps
N-Cyclohexyl 4-chlorobenzamide (12.8 g, 53.9 mmole) and thionyl chloride (43.14 g, 363 mmole) were heated at reflux with stirring for 1.75 hours. Excess thionyl chloride was removed by distillation. The title compound was isolated by distillation (b.p. 130° C. at ~15 mm Hg) to yield 7.4 g (54%) of a clear colorless liquid which crystallized upon cooling.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04528382 |
| Source dataset | uspto-grants-1985_07 |
| ORD ID | ord-1a7be2027218483d9b1209200e215c66 |
| Source note | uspto-grants-1985_07 |