Pyridinium chloride → HCID 13290022, compound

HRID 370957Notes

Reaction equation

HRID 370957 reaction equation
[Cl:1][C:2]1[C:3]([O:13]C)=[CH:4][C:5]2[CH:9]=[C:8]([CH3:10])[S:7][C:6]=2[C:11]=1[Cl:12].Cl.N1C=CC=CC=1>O>[Cl:1][C:2]1[C:3]([OH:13])=[CH:4][C:5]2[CH:9]=[C:8]([CH3:10])[S:7][C:6]=2[C:11]=1[Cl:12]

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 13290014HCID 13290014, compound

Product 1

HCID 13290022HCID 13290022, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 4.8 g of 6,7-dichloro-5-methoxy-2-methylbenzo[b]thiophene and 40 g of pyridine hydrochloride is stirred at 190° for 3 hours. The cooled mixture is diluted with 500 ml of water. The solid is collected and air-dried. Recrystallization from ether-hexane mixture gives 6,7-dichloro-5-hydroxy 2-methylbenzo[b]thiophene as off-white crystals, mp 93°-95° C.

Workup

  1. customThe solid is collected
  2. customair-dried
  3. customRecrystallization from ether-hexane mixture

Sources & evidence

ORD record
ord-038246dcf8e64d56b0eeb841ef84fcf0
Source dataset
uspto-grants-1985_07
Patent number
US04528399

Reaction notes

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