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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 37099Generated: October 26, 2026

Thiophene-3-carboxylic acid → Thiophene-3-carboxylic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-5-(2-chloro-5-methoxy-phenoxy)-pyrimidin-4-ylmethoxy]-ethyl ester

https://huagongshe.com/reaction/37099

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThiophene-3-carboxylic acidHCID 6918—
Reactant4-tert-butyl-N-[5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy-methyl)-pyrimidin-4-yl]-benzenesulphonamideHCID 19934741—
ProductThiophene-3-carboxylic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-5-(2-chloro-5-methoxy-phenoxy)-pyrimidin-4-ylmethoxy]-ethyl esterHCID 19934733—

Reaction Steps

By reacting 4-tert-butyl-N-[5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy-methyl)-pyrimidin-4-yl]-benzenesuiphonamide with 3-thiophencarboxylic acid there was obtained thiophene-3-carboxylic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-5-(2-chloro-5-methoxy-phenoxy)-pyrimidin-4-ylmethoxy]-ethyl ester. MS: M=631.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05420129
Source datasetuspto-grants-1995_05
ORD IDord-9a581d10c4c64f54a1f060b160a1d485
Source noteuspto-grants-1995_05