反应详情

温度

245 °C

A mixture of 8.97 g (0.04 mole) of tetrahydro-3-benzyl-5,5-dimethyl-1,3-oxazin-2-one and 0.084 g (0.002 mole) of lithium chloride was heated to 245° C. at a pressure of 100 torr in a 25-ml flask equipped with a mechanical stirrer and distillation head. The receiver was cooled with dry ice as the product slowly distilled. After 5 hours, an additional 0.084 g of lithium chloride was added and heating was continued for an additional 25 hours. At this time, 5.84 g (85 percent yield) of pure 1-benzyl-3,3-dimethylazetidine had collected. The material was redistilled at bp 107° C.-108° C. (15 mm).

1. customequipped with a mechanical stirrer
2. distillationdistillation head
3. temperatureThe receiver was cooled with dry ice as the product
4. distillationslowly distilled
5. additionan additional 0.084 g of lithium chloride was added
6. temperatureheating
7. waitwas continued for an additional 25 hours