HCID 13375774, compound → HCID 70400268, compound

Participants

Reaction Steps

A solution of (11β,17β)-11-(acetyloxy)-9-fluoro-17-(methylthio)androsta-1,4-dien-3-one (2.0 g; 5.09 mmole) in a mixture of methanol (15 ml) and tetrahydrofuran (15 ml) was flushed well with nitrogen, 3M aqueous sodium hydroxide (2.0 ml) was added and the mixture was stirred at room temperature for 45 minutes. A moderate excess of acetic acid was added, the mixture was concentrated in vacuo and was diluted with water. The steroid that separated was isolated by filtration, washed with water, dried, crystallized from ethyl acetate-hexane and dried (100° C., 0.3 mm of Hg, 10 hours) to afford the homogeneous (tlc) analytical specimen of the title commpound (1.4 g), melting point 269°-270° C. with consistent spectral data.

Provenance & Evidence