m-Chloroperbenzoic acid → (11beta,17beta)-17-(Ethylsulfinyl)-9-fluoro-11-hydroxyandrosta-1,4-dien-3-one

Participants

Reaction Steps

To a solution of (11β,17β)-17-(ethylthio)-9-fluoro-11-hydroxyandrosta-1,4-dien-3-one (700 mg, 1.92 mmole; see example 6) in chloroform (30 ml) was added a solution of 86% m-chloroperbenzoic acid (390 mg, 1.95 mmole) in chloroform (15 ml). An instantaneous reaction was noted (tlc). The solution was then washed with a 10% potassium carbonate solution and water, dried (anhydrous magnesium sulfate) and evaporated to afford the title compound (697 mg) as a solid. One crystallization of this from ethyl acetate followed by drying (100° C., 0.3 mm of Hg, 10 hours) gave the analytical specimen of the title compound (600 mg), melting point 247°-250° C., with consistent spectral data.

Provenance & Evidence