HCID 13589827, compound → HCID 13589829, compound

Participants

Reaction Steps

8.00 g (11.5 mmols) of 10-(N-tert-butoxycarbonyl-O-benzyl-L-seryl)-1,5-dibenzyloxycarbonyl-1,5,10-triazadecane was dissolved in 8.0 ml of trifluoroacetic acid, and the solution was stirred for 3 hours at room temperature. The reaction mixture was concentrated under reduced pressure, and the residual oil was dissolved in 200 ml of ethyl acetate. The solution was washed with a 5% aqueous solution of sodium hydrogencarbonate and distilled water in this order, and the ethyl acetate layer was dried over anhydrous sodium sulfate. After the desiccant was removed by filtration, the filtrate was concentrated under reduced pressure to obtain 6.82 g (quantitative) of the desired product as an oily substance.

Provenance & Evidence