Phenylacetyl chloride → 3-(Phenylacetyl)-2-nitromethylene-tetrahydro-2H-1,3-thiazine

Participants

Reaction Steps

To a solution of phenylacetyl chloride (4.8 g) in dry dichloromethane (30 ml) at -20° C. was added triethylamine (5.2 ml) over a period of 20 minutes, followed by 2-(nitromethylene)-tetrahydro-2H-1,3-thiazine (3.2 g) in dry dichloromethane (30 ml) over a period of 20 minutes. The reaction mixture was allowed to warm to ambient temperature with stirring over a period of 30 minutes and was then worked up in a similar manner to that described in Example 1 to yield the required product as a white crystalline solid m.p. 121°-122° C.

Provenance & Evidence