HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 20262414, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | 6-(2-(4-(1H-Indol-3-yl)piperidin-1-yl)ethyl)-3,7-dimethyl-5H-thiazolo(3,2-a)pyrimidin-5-one | HCID 3086107 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 20262414 | HCID 20262414 | 80% |
Reaction Steps
A stirred and warm suspension of 4 parts of 6-[2-[4-(1H-indol-3-yl)-1-piperidinyl]ethyl]-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one in 80 parts of ethanol was acidified with phosphoric acid. 60 parts of water were added and the whole was boiled. The undissolved material was filtered off and the filtrate was allowed to crystallize. The product was filtered off and dried, yielding 4.5 parts (80%) of 6-[2-[4-(1H-indol-3-yl)-1-piperidinyl]ethyl]-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one phosphate (2:3) monohydrate; mp. 214.4° C. (compound 28).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04529727 |
| Source dataset | uspto-grants-1985_07 |
| ORD ID | ord-d9a01389ac6a4d459c90fdd5f5812f19 |
| Source note | uspto-grants-1985_07 |