Hydrochloric Acid → HCID 54074270, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl (2-carboxy-2-chlorovinyl)thioacetate (1) (1.48 g), pyridine (0.65 ml), and ethyl chlorocarbonate (0.6 ml) is stirred in THF at -30° C. for 5 minutes and subsequently at 0° C. for 10 minutes. Sodium borohydride (0.8 g) is added thereto, and the mixture is stirred at 0° C. for 2 hours. The reaction mixture is poured into dil. HCl and extracted with ethyl acetate. The ethyl acetate extract is washed with water, concentrated in vacuo, and chromatographed over silica gel to give methyl (2-hydroxymethyl-2-chlorovinyl)thioacetate (2). Yield: 492 mg.

Provenance & Evidence