Aluminium lithium hydride → HCID 70491804, compound

HRID 371157Notes

Reaction equation

HRID 371157 reaction equation
[C:1]([N:5]1[CH2:10][CH2:9][C@H:8]([O:11]C(=O)CC)[CH2:7][C@@H:6]1[C:16]1[CH:21]=[CH:20][C:19]([C:22]([CH3:30])([CH3:29])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:18][C:17]=1[O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)(=O)[CH2:2][CH3:3].[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH2:1]([N:5]1[CH2:10][CH2:9][C@H:8]([OH:11])[CH2:7][C@@H:6]1[C:16]1[CH:21]=[CH:20][C:19]([C:22]([CH3:29])([CH3:30])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:18][C:17]=1[O:31][CH2:32][C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 70491052HCID 70491052, compound

Product 1

HCID 70491804HCID 70491804, compoundYield 88.3%

Procedure

Using the procedure of Example 5, 723 mg (1.46 mmole) of N-propionyl-cis-2-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4-propionyloxypiperidine and 129 mg (3.40 mmole) of lithium aluminum hydride gives 582 mg (88%) of the title compound as an oil.

Sources & evidence

ORD record
ord-1215f46e6cd7448faa7006b8edebb8c5
Source dataset
uspto-grants-1985_07
Patent number
US04529732

Reaction notes

Loading…