HCID 70491804, compound → HCID 70491903, compound

HRID 371158Notes

Reaction equation

HRID 371158 reaction equation
[CH2:1]([N:4]1[CH2:9][CH2:8][C@H:7]([OH:10])[CH2:6][C@@H:5]1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([CH3:25])([CH3:24])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:13][C:12]=1[O:26]CC1C=CC=CC=1)[CH2:2][CH3:3]>[Pd]>[CH2:1]([N:4]1[CH2:9][CH2:8][C@H:7]([OH:10])[CH2:6][C@@H:5]1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([CH3:24])([CH3:25])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:13][C:12]=1[OH:26])[CH2:2][CH3:3]

Participants

3

Reactant 1

HCID 70491804HCID 70491804, compound

Product 1

HCID 70491903HCID 70491903, compoundYield 94.2%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Employing the procedure of Example 4, 535 mg (1.18 mmole) N-propyl-cis-2-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4-piperidinol and 212 mg 5% palladium on carbon (50% wet) gives 402 mg (94%) of the title compound as an oil.

Sources & evidence

ORD record
ord-e665a047291a4fa2ac54af9da1bf1320
Source dataset
uspto-grants-1985_07
Patent number
US04529732

Reaction notes

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