HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N-(2-Propynyl)-cis-2-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]-4-piperidinol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Propyne, 1-bromo- | HCID 137279 | — |
| Reactant | cis-2-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-4-piperidinol | HCID 13519478 | — |
| Product | N-(2-Propynyl)-cis-2-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]-4-piperidinol | HCID 86740205 | 57% |
Reaction Steps
Employing the procedure of Example 10 with 321 mg (1.01 mmole) of cis-2-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]-4-piperidinol, 82 microliter (1.06 mmole) or propynyl bromide and 292 mg (2.12 mmole) of potassium carbonate affords 205 mg (57%) of the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04529732 |
| Source dataset | uspto-grants-1985_07 |
| ORD ID | ord-369fd318923a4ab2b381bdc985bb373d |
| Source note | uspto-grants-1985_07 |