Chloral → HCID 13193057, compound

Participants

Reaction Conditions

Reaction Steps

14.8 g (0.1 mol) of chloral were added dropwise to 7.6 g (0.05 mol) of 1,2,4-triazol-1-yl-acetyl-cyclopropane, 7.5 g of glacial acetic acid and 4.1 g (0.05 mol) of sodium acetate, the internal temperature increasing to approx. 42° C. The reaction mixture was stirred for 5 hours at 80° C. and for 12 hours at room temperature, and was then introduced onto water. The resulting precipitate was filtered off under suction and recrystallized from toluene. 8.6 g (57.6% of theory) of 1,1,1-trichloro-2-hydroxy-3-(1,2,4-triazol-1-yl)-4-cyclopropyl-butan-4-one of melting point 173° to 175° C. were obtained.

Provenance & Evidence