1H-1,2,4-Triazole → HCID 20273714, compound

Participants

Reaction Steps

A mixture of 1.78 g (37 mmol) of 50% sodium hydride, 30 ml of dimethylformamide, and 2.56 g (37 mmol) of 1H-1,2,4-triazole is stirred at 50° for one hour, and a solution of 10 g (33.7 mmol) of a 1:1 mixture of allyl[bis(4-fluorophenyl)]-1-chloroethylsilane and allyl[bis(4-fluorophenyl)]-2-chloroethylsilane in 10 ml of dimethylformamide is added. The mixture is stirred at 50° for 64 hours, cooled, diluted with water, and extracted with ether. The ether extracts are washed with water and brine, dried over sodium sulfate, and evaporated to leave a viscous oil. Chromatography over silica gel eluting with 4:1 dichloromethane-acetone provides the title compound.

Provenance & Evidence