Phosphoric Acid → HCID 178516367, compound

HRID 37132Notes

Reaction equation

HRID 37132 reaction equation
C(OC([C:6]1[CH:7]=[N:8][C:9]2[N:10]([N:13]=[CH:14][C:15]=2[C:16]2[CH:21]=[CH:20][C:19]([S:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:18][CH:17]=2)[C:11]=1[OH:12])=O)C.P(=O)(O)(O)O>O>[OH:12][C:11]1[N:10]2[N:13]=[CH:14][C:15]([C:16]3[CH:21]=[CH:20][C:19]([S:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[CH:18][CH:17]=3)=[C:9]2[N:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 178469484HCID 178469484, compound

Product 1

HCID 178516367HCID 178516367, compoundYield 79.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
170 °C

Procedure

A mixture of 3.91 g of 6-ethoxycarbonyl-7-hydroxy-3-(4-phenylthiophenyl)-pyrazolo[1,5-a]pyrimidine obtained in Example 1 and 30 ml of 85% phosphoric acid was heated in a heating bath to 170° C., and stirred for 30 minutes, and the mixture gradually developed foams, and the foams were about to cease, the reaction solution turned to a dark red color. Stopping the heating bath, 200 ml of water was added, and after letting stand for 30 minutes while ice-cooling, the precipitate was filtered, washed in water and dried, and 2.55 g of the title compound was obtained.

Workup

  1. additionwas added
  2. customfor 30 minutes
  3. temperaturecooling
  4. filtrationthe precipitate was filtered
  5. washwashed in water
  6. customdried

Sources & evidence

ORD record
ord-49209c6b41a44547a6c0b7eb11a8a3b1
Source dataset
uspto-grants-1995_05
Patent number
US05420128

Reaction notes

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