Potassium Carbonate → HCID 13519821, compound

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A mixture of succinimide (1, 3.2 g, 31.6 mmol) and ethyl 7-bromoheptanoate (5 g, 21 mmol) in dimethylformamide (30 mL) containing potassium carbonate (3.5 g, 25 mmol) was heated at about 55° to 60° C. for twenty hours. The mixture was then diluted with ether and washed twice with water, once with saturated aqueous sodium chloride, and dried over magnesium sulfate. Removal of the solvent under reduced pressure gave the crude product which was purified by high performance liquid chromatography (HPLC) to give 3.66 g of 7-(2-oxo-5-oxopyrrolidin-1-yl)heptanoic acid, ethyl ester, 2. IR (neat): 1775, 1735, 1700 cm-1 ; PMR (CDCl3): δ 4.10 (q, J=7, 2H), 3.46 (t, J=7, 2H), 2.67 (s, 4H), 2.26 (t, J=7, 2H), 1.77-1.11 (m, 8H), and 1.23 (t, J=7, 3H).

Provenance & Evidence