反应详情

To a solution of 16 (about 4 mg) in ethanol (0.5 mL) at 0° was added sodium borohydride (3 mg). The mixture was stirred at 0° for one hour and then quenched with one drop of acetic acid. After removing ethanol, the residue was diluted with methylene chloride and washed with saturated sodium chloride. The separated aqueous layer was extracted with methylene chloride twice and the combined organic layer was dried over magnesium sulfate. Removal of the solvent gave 2.7 mg of methyl 7-[2-(2-hydroxy-2-methylheptylthio)-5-oxopyrrolidin-1-yl]-6-hydroxyheptanoate, 17. By comparison of TLC mobility, this product was determined to be identical in element content to that of Example 4.

1. customquenched with one drop of acetic acid
2. customAfter removing ethanol
3. additionthe residue was diluted with methylene chloride
4. washwashed with saturated sodium chloride
5. extractionThe separated aqueous layer was extracted with methylene chloride twice
6. dry with materialthe combined organic layer was dried over magnesium sulfate
7. customRemoval of the solvent