Sulfuric Acid → HCID 20273828, compound

HRID 371341Notes

Reaction equation

HRID 371341 reaction equation
[NH2:1][C:2]1[S:3][N:4]=[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=12.[OH:11][S:12](O)(=[O:14])=[O:13]>CC(C)=O>[NH2:1][C:2]1[S:3][N:4]=[C:5]2[C:10]([S:12]([OH:14])(=[O:13])=[O:11])=[CH:9][CH:8]=[CH:7][C:6]=12

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 122930582,1-Benzothiazol-3-amine

Product 1

HCID 20273828HCID 20273828, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 10.0 g. of 3-amino-2,1-benzisothiazole in 100 g. of concentrated H2SO4 was heated at 50°-55° C. for one-half hour, then cooled and added to 500 ml. of cold acetone. The product was removed by filtration and then reprecipitated from bicarbonate solution by addition of sufficient acetic acid to give a pH of 4.75-4.80. 8.5 Grams of purified 3-amino-2,1-benzisothiazole-7-sulfonic acid product was obtained.

Workup

  1. temperaturecooled
  2. additionadded to 500 ml
  3. customThe product was removed by filtration
  4. customreprecipitated from bicarbonate solution by addition of sufficient acetic acid
  5. customto give a pH of 4.75-4.80

Sources & evidence

ORD record
ord-0df0c258263849d7b49bc04623f7532b
Source dataset
uspto-grants-1985_07
Patent number
US04530997

Reaction notes

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