Citric Acid → HCID 13503172, compound

Participants

Reaction Steps

In the same manner as in (1) of Example 1, 10.45 g (0.015 mole) of Boc-Trp-Met-Asp-Phe-NH2 [cf. (1) of Example 3] was condensed with 9.00 g (0.022 mole) of Boc-Trp-OSu. The resulting reaction liquid was concentrated, and a precipitate was formed by adding 1N citric acid and washed with water. Recrystallization thereof from methanol-water gave 8.09 g of Boc-D-Trp-Trp-Met-Asp-Phe-NH2 ; yield 61.1%, m.p. 225°-227° C.

Provenance & Evidence