Sodium Hydroxide → HCID 178487644, compound

HRID 37138Notes

Reaction equation

HRID 37138 reaction equation
[OH:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]3[CH:16]=[CH:15][C:14]([S:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)=[C:13]([O:24][CH3:25])[CH:12]=3)=[C:6]2[N:5]=[CH:4][C:3]=1C(OCC)=O.[OH-].[Na+]>O1CCOCC1>[OH:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]3[CH:16]=[CH:15][C:14]([S:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)=[C:13]([O:24][CH3:25])[CH:12]=3)=[C:6]2[N:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178469485HCID 178469485, compound

Product 1

HCID 178487644HCID 178487644, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 340 mg of 7-hydroxy-6-ethoxycarbonyl-3-(3-methoxy-4-phenylthiophenyl)pyrazolo[1,5-a]pyrimidine, 15 ml of dioxane and 2 ml of aqueous solution of 2N sodium hydroxide were added, and heated and refluxed for 1 hour. The reaction mixture was concentrated in vacuo, and 30 ml of water was added to the residue, which was neutralized with acetic acid. The precipitate was filtered, washed with water and dried, and the title compound was obtained (260 mg)

Workup

  1. temperatureheated
  2. temperaturerefluxed for 1 hour
  3. concentrationThe reaction mixture was concentrated in vacuo, and 30 ml of water
  4. additionwas added to the residue, which
  5. filtrationThe precipitate was filtered
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-f65dd5da740f4564bd3a2a87ad74af8a
Source dataset
uspto-grants-1995_05
Patent number
US05420128

Reaction notes

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