Sodium Hydroxide → HCID 178520336, compound

HRID 37141Notes

Reaction equation

HRID 37141 reaction equation
C([O:4][CH2:5][CH2:6][C:7]1[CH:8]=[N:9][C:10]2[N:11]([N:14]=[CH:15][C:16]=2[C:17]2[CH:22]=[CH:21][C:20]([S:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[CH:19][CH:18]=2)[C:12]=1[OH:13])(=O)C.[OH-].[Na+]>CO>[OH:13][C:12]1[N:11]2[N:14]=[CH:15][C:16]([C:17]3[CH:18]=[CH:19][C:20]([S:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:21][CH:22]=3)=[C:10]2[N:9]=[CH:8][C:7]=1[CH2:6][CH2:5][OH:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178476196HCID 178476196, compound

Product 1

HCID 178520336HCID 178520336, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a methanol suspension of 180 mg of 6-(2-acetoxyethyl)-7-hydroxy-3-(4-phenylthiophenyl)pyrazolo[1,5-a]pyrimidine, 2 ml of 2N sodium hydroxide was added, and stirred for 21 hours at room temperature. Turning acidic with 10% hydrochloric acid, the precipitate was filtered, washed with-water, dried, and the title compound was obtained (150 mg, 93%).

Workup

  1. additionwas added
  2. filtrationTurning acidic with 10% hydrochloric acid, the precipitate was filtered
  3. washwashed with-water
  4. customdried

Sources & evidence

ORD record
ord-12cf7244411f4f7a9a01904007c5e0a1
Source dataset
uspto-grants-1995_05
Patent number
US05420128

Reaction notes

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