反应详情

50 millimols each of ethyl 4-acetoxy-3-oxo-butyrate, ethyl 3-aminocrotonate and 2-trifluoromethylbenzaldehyde in 100 ml of ethanol were boiled under reflux for 24 hours, 2 g of potassium hydroxide were then added, and the mixture was boiled for a further hour. After the mixture had cooled, the product was precipitated with a water/sodium chloride mixture and was recrystallized from methanol.

1. temperatureunder reflux for 24 hours
2. waitthe mixture was boiled for a further hour
3. temperatureAfter the mixture had cooled
4. customthe product was precipitated with a water/sodium chloride mixture
5. customwas recrystallized from methanol