Acetic Anhydride → HCID 13121196, compound

HRID 371417Notes

Reaction equation

HRID 371417 reaction equation
[NH2:1][C:2]1[NH:3][C:4]([CH3:19])=[C:5]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:6]([CH3:13])[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9].[C:20](OC(=O)C)(=[O:22])[CH3:21]>>[C:20]([NH:1][C:2]1[NH:3][C:4]([CH3:19])=[C:5]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:6]([CH3:13])[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9])(=[O:22])[CH3:21]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 12391086Diethyl 2-amino-4,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Product 1

HCID 13121196HCID 13121196, compound

Procedure

8 g (0.03 mol) of diethyl 2-amino-4,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate in 100 ml of acetic anhydride were boiled under reflux for 4 hours. The mixture was concentrated to dryness in vacuo, and the residue was recrystallized from ethanol. Yield: 5.4 g (58% of theory) of m.p.: 105° C.

Workup

  1. temperatureunder reflux for 4 hours
  2. concentrationThe mixture was concentrated to dryness in vacuo
  3. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-1015a77423aa488a9dd8cae97ba82a5c
Source dataset
uspto-grants-1985_07
Patent number
US04532248

Reaction notes

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